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February 19, 2015

Making A Boat Of Plastic Bottles

A plastic bottle is a bottle made out of plastic. Plastic bottles are usually used to store liquids such as water, soft drinks, motor oil, cooking oil, medicine, shampoo, milk, and ink. The size ranges from very small sample bottles to large carboys.

Plastic bottles were first used commercially in 1947, but remained relatively expensive until the early 1960s when high-density polyethylene was introduced.

They quickly became popular with both manufacturers and customers due to their lightweight nature and relatively low production costs compared with glass bottles. Except for wine and beer, the food industry has almost completely replaced glass with plastic bottles.

There is an ongoing concern as to the use of some plastics in consumer food packaging solutions. The environmental impact of the disposal of these products, as well as concerns regarding consumer safety, are still debated.

Plastic water bottles are regulated by the FDA. The FDA periodically samples bottled water and also inspects bottled water plants. Plastic water bottle plants hold a low priority for inspection due to a continuously good safety record.  

This Has To Be The Worst Place To Sit

Sitting is a position of human body that is supported by the buttocks or thighs where the torso is more or less upright.

The origins of the position are in dispute. Although many art pieces of Antiquity show individuals in various stages of sitting, it is thought that it did not become common practice until well into the 19th Century. Henri, Count of Chambord claimed to have invented sitting in 1834, but much like his alleged seven day reign as King of France, many challenge the veracity of the claim.

The most common way of sitting on the floor involves bending the knees. One can also sit with the legs unbent, using something solid as support for the back or leaning on one’s arms.

Sitting with bent legs can be done along two major lines; one with the legs mostly parallel and one where they cross each other. The parallel position is reminiscent of, and is sometimes used for, kneeling. The latter is a common pose for meditating.

One variation that is highly unusual is the ‘chicken wing’ style. One would have their legs outwards facing backwards instead of folding them in front of them-self.

New Skin Cancer Drug Set For Clinical Trials

Almost 13,000 people in the UK are diagnosed with melanoma and around 2,000 people die every year from the disease. It’s one of the most common cancers to affect 15-34 year olds although it is still mostly found in older patients. Melanoma is slightly more common in females than in males. A team of scientists from Cancer Research UK at institutes in London and Manchester have been running laboratory tests on two compounds which have been shown to have encouraging results in treating melanoma. Although promising, these laboratory trials are only the first step in drug discovery and it will be some time before any conclusive evidence is available.

Melanoma

Melanoma is the most serious form of skin cancer as it spreads quickly and can soon affect lymph nodes and other organs if not treated quickly. 76,000 cases of melanoma were reported with around 9,000 deaths in the U.S. and more than 100,000 cases with 22,000 deaths in Europe were reported. It is often diagnosed when the shape or size of an existing mole is noticed to have changed or new moles appear. It is important to see your doctor as soon as possible if you notice any of these changes. Melanoma can appear anywhere on the body but it is most commonly found on the back, arms and legs. Sunburn is often seen as a contributing factor and it can indeed lead to melanoma.

New Compounds

The two compounds that have been undergoing laboratory testing are a type of compound that are known as signal inhibitors. These are designed to stop the cancer cells sending messages to each other to co-ordinate the cancers growth. The two compounds which are together known as panRAF inhibitors work slightly differently to previous drugs and could potentially be used in patients with advanced melanoma that has become resistant to previous treatments. Although initial results on lab mice have been promising, use on human patients may prove the drug to be ineffective or even dangerous.

The new compounds were discovered as researchers tried to find new ways of fighting resistant forms of melanoma. The two compounds were found in a group of different compounds that were being tested as part of a drug discovery program. The two compounds then underwent more thorough testing and analysis to get them to the point where the researchers could begin testing on mice. Testing on the mice was promising as the cancer cells were successfully destroyed and the mice didn’t appear to have suffered any side effects.

Targeting Multiple Cancer Proteins

Up to half of melanoma cases diagnosed are those which have a specific mutation in the BRAF gene and the related MEK protein. Up until now, drugs have been used to stop this mutation in one specific gene or another but not multiple genes at once. It has been found that drugs that are used to fight these cases are initially effective but the cancer would often return after a period of time when it started to become resistant to the drugs. Now research has turned towards to the goal of combining a BRAF inhibitor with a MEK protein inhibitor in the hope that this will give longer lasting results. Targeting multiple cancer proteins at once will stop the cancer becoming resistant to the drug. It was also found that the panRAF inhibitors stopped growth in tumours that previous BRAF targeted drugs had failed to have any effect on and this accounts for a further 20% of melanoma cases.

Trialling the New Drug

Now that the drug has been given the go ahead for clinical trials the first step in this will be a small scale trail that focuses on getting the dosage right and watching for any safety concerns such as side effects. Although not specifically looking for effectiveness it is hoped that this initial trial will show some signs of it. If the first round of trials are successful then it will be tested on a much larger scale and the drug’s effectiveness will be the main focus. If it is eventually found to be an effective drug in the treatment of malignant melanoma it is likely to be used as a first line treatment for patients and also a second line treatment in patients with resistant form of the disease.

Although initially results have been promising, the fact that the compounds have yet to have been trialled in human patients means that there are potentially still many years of clinical trials left to establish whether or not it is effective in human patients and there are no guarantees that an effective drug will come from all the testing.

This post is written by Jane Freeman, a blogger for  Cedars Dermatology.

5 Websites and Apps Every Londoner Needs

Whether you are new to London, are just visiting or have lived there a while. Knowing about all the best places to go and things to see can be almost impossible without a lifetime to find them for yourself or knowing someone who already has a great knowledge of the city. However, there are some resources available that can allow you to bypass this and find the best places for yourself in no time at all. By using the following websites and mobile apps, you’ll be showing all your friends the best things to see and do in the capital.

London Official Guide


This app available for iPhone gives access to maps and guides which can be viewed offline. This free app has some great guides and shows the top things to do in London which can be searched by category or location. Another great feature is the ability to plan out your day in the capital. With a personalised itinerary which will include step by step directions on how to get to each attraction. Bars, cafes and restaurants can be found with detailed reviews of each and local amenities such as police stations and pharmacies can be quickly found. Roaming charges can be avoided due to the fact that all these services are available offline. Update your itinerary before leaving a WiFi hot spot (which can also be found within the guide), then you’re all set for the day. The app will even recommend places to visit depending on the current weather or time of day. All in all, if you’re planning a day out in London don’t leave home without this app.

Recce


Recce gives you an interactive 3D map shows what’s in and around your current location giving you a detailed overview of the area. The map is the main feature of the app giving you a 3D view of your surroundings and a compass so you never get lost again. The 3D view shows a cartoon overview of the city which can easily be navigated and zoomed to view points of interest. Its powerful search function allows you to find anything you want nearby such as restaurants, places of interest and transport links. The app is integrated with Transport for London’s real time information so you can find up to the minute details of tube, bus and bike hire close by. You are able to access social media from within the app to find reviews and news on the go. Not just for London, Recce is available for a host of major cities in the UK and USA. The app is available for iOS and android and more features and cities are being added all the time.

Hailo


Hailo is the worlds highest rated taxi app. This great app will never leave you stuck without a lift home. If you are looking for a black cab or executive car to pick you up, all you need to do is to input your pick up and drop off locations and Hailo will do the rest. Using the app you can track your car and can even pay for the service within the app so you never need to worry about having the cash to pay the driver again. The app includes a fare quote with which you can get an estimate for the trip and all trip histories and receipts are stored so you can access them whenever you need to. Not just serving London, Hailo serves major cities across the globe including New York, Boston, Montreal and Toronto so wherever you are, you can always find a cab.

Just Park


If you’ve travelled to London before then you know that parking can be a nightmare. Even if you manage to find a space close to your destination, you are probably going to pay a fortune to stay for even a few hours. With Just Park you never have to worry again. Simply search the Just Park site for your ideal parking space and you can reserve a spot and even save up to 60% on traditional on street parking. If you are heading into London for a show, or just a day trip. Knowing that you already have a reserved parking space before you arrive takes all the stress away, leaving you able to enjoy your stay in the capital.

CapitalAlist.com


Capital A List  is the one stop shop for all your exclusive party and clubbing needs. Offering not only a guest list service for the hottest clubs in town and a second to none table booking service.  If you’re looking for a more exclusive and personally crafted night out, then you can’t go wrong with the table booking service. Whether you are looking for the perfect night out for you and your friends, or showing your clients the best the capital has to offer.

This post is written by Jane Freeman who is a freelance content marketer in the travel industry.

Clothing Brands Help with Clothing Recycling Program

In the event that you or somebody you know has an old pair of denim pants they are attempting to dispose of, then maybe giving these jeans would be a keen alternative. By giving a couple of pants or whatever other denim piece of attire, $20 will go to your following visit to J. Team or Madewell at whatever point you purchase denim pants. J.Crew Brands Extend Partnership with Blue Jeans Go Green. Thusly, all the denim materials can be utilized to help associations devoted to helping groups across the country.

For every year, around 250,000 square feet of protection are conveyed on account of Blue Jeans Go Green, a system ran by Cotton Incorporated. All the denim make up the protection, which is then used to diminishing 1.2 million pounds of landfill waste.

 These stores are taking an interest, as well as school understudies are having any kind of effect, as well. Promoting understudies have been attempting to gather denim and concentrate on ecological and group issues. The brands are excited to at the end of the day bring Blue Jeans Go Green™ to universities over the U.s. The project is an incredible route for understudies to include their associates and bring attention to their yards.. Take in more by going by jcrew.com or madewell.com

This post was sponsored, but opinions are my own

Turning A Ball Of Fur Into A Dog

Fur is a term used to reference to the hair of animals, usually mammals, particularly those with extensive body hair coverage. The term “pelage” can also be used to refer to the body hair of an animal as a complete coat.

Fur is also used to refer to animal pelts which have been processed into leather with the hair still attached. The words fur or furry are also used, more casually, to refer to hair-like growths or formations, particularly when the subject being referred to exhibits a dense coat of fine, soft “hairs.”

Animal fur, if layered, rather than grown as a single coat, may consist of short down hairs, long guard hairs, and, in some cases, medium awn hairs. Mammals with reduced amounts of fur are often called “naked”, such as naked mole rat and naked dogs.

An animal with commercially valuable fur is known within the fur industry as a furbearer. The use of fur as clothing and/or decoration is considered controversial by some people: most animal welfare advocates object to the trapping and killing of wildlife and to the confinement and killing of animals on fur farms.

Fur has been a major challenge for 3D computer graphics artists due to its visual complexity and physical properties. The first movie that managed to create realistic fur with CGI was Pixar’s 2001 film Monsters, Inc.

Some bizarre martial arts you didn’t know existed

There are martial arts and there are some really out-there martial arts you just wouldn’t believe.

 martial-arts

by  blmurch

We all know about karate, judo, kung fu and so forth, but there are now other martial arts on the scene that may seem new, but have actually been around for a long time. Amongst these is the official version of mixed martial arts, which has evolved so prominently in recent years that the gambling exchange Betfair even now offers markets on the sport. This kind of thing goes to illustrate just how mainstream some martial arts have become. As for the following eight versions of trying to pound an opponent into oblivion in as many ways as possible – well let’s just say we don’t expect any kind of formal betting market to develop any time soon. You’ll soon find out exactly why that is…

Bokator

Bokator is a Cambodian fighting method that takes some believing. It goes all the way back to the battlegrounds of Indochina from over 17 centuries back. Bokator is designed to mimic the movements of certain animals, including cranes, eagles, snakes, horses, and lions.

Bokator is particularly notable for its sheer brute force. If you imagine yourself on a battlefield at a time before firearms, you’d have to be pretty efficient. Bokator includes moiré than 10, 000 different techniques, including knee and elbow hits, joint locks, and a host of different throws. Bokator really has to be seen to be believed.

Bakom

Moving to the other side of the world now and, specifically, to Peru – Bakom (also called Vacón) is a product of the poverty-stricken back streets of Lima. It is a particularly harsh and quick martial art designed to kill or disable an opponent immediately. It may also include hidden weapons.

Bakom isn’t an ancient form though, by any means. In fact, it was developed by an ex Marine and former convict, Roberto Puch Bezada, as recently as the 1980s. Bakom borrows heavily from both jujutsu and Vale Tudo-style street fighting.

Amongst its delightful menu of moves are bone-snapping arm locks, vicious chokeholds, and precision hits at vital organs. This all happens at an incredibly quick pace designed to finish the opponent off before he’s even had a chance to think!

 

Lerdrit

Lerdrit is a recent version of traditional Thai fighting methods. It is used today by the highly trained commandos of Thailand’s Royal Army. Lerdrit is similar to its predecessors called “Muay Thai” and “Muay Boran” but it’s also been honed to vicious perfection for the needs of the modern world.

Specifically, practitioners are instructed to attack without warning, and to knock the target to the ground immediately then to finish them off with a charming “kill strike” like a boot to the throat (it isn’t overly subtle). An elbow to the opponent’s temple is another Lerdrit move!

Dambe

Dambe is practiced in West Africa and is based on ancient Egyptian hand to hand fighting techniques.

The Hausa people use the technique most heavily. The main weapon with Dambe is the “strong side fist”. This is where the lower arm is wrapped cloth covered and very tightly woven cord, whilst one of the fighter’s legs is wrapped in a thick chain. These two weapons are then used to beat the heck out of your opponent before he does it to you!

 

Jailhouse Rock (JHR)

Jailhouse Rock – or simply “JHR” is nothing to do with Elvis Presley unfortunately.

Instead, it’s a particularly ferocious form of fighting developed – as the name suggests – in prisons in the USA by prisoners with a lot of time and a lot of weight-training equipment on their hands.

There are few rules but this is a recognized martial art – one of only two such recognized martial arts from the US. It is notable for its bizarre and brutal training techniques – like picking up a pack of cards one by one in a room whilst being beaten by a group of other guys.

Kalari Payat

Kalari Payat comes from the southern Indian state of Kerala, which many tourists know as a beach paradise. It’s supposed to be the oldest form of organized fighting technique known to mankind.

There are various versions and sub-versions of Kalari Payat used in either armed or unarmed combat.

Most involve disabling an opponent by hitting him in vital points. There are over 100 points on the body considered to be vital making it therefore essential to hit as hard as you possibly can – preferably with a particularly hard part of your own body!

 

Silat

Silat is actually a collective term for a group of martial arts first developed in the Philippines, Malaysia and Singapore by old headhunting tribes. There are hundreds of different types of Silat styles and techniques include good old-fashioned hitting, grappling, throws, joint manipulation and sharp-edged weapons.

It’s been around forever – but the techniques are used still today by various armies in the region!

Okichitaw

Last but not least, we’re back in North America for a look at fighting techniques used by American Indians. It’s one of the last-known such examples in fact.

Okichitaw is based on the combat techniques of the Plains Cree American Indians. The modern version was founded and developed by one George J. Lepine, a man who studied student tae kwan do, judo and hapkido. George also worked on his tomahawk-throwing techniques and made use of the gunstock war club. Consequently, Okichitaw is now a hybrid martial art that puts together the legendary American Indian ferocity with various Asian martial art techniques and is, therefore, pretty deadly.

The whole principle with Okichitaw is to use the hands as if they were weaponry – the hands are supposed to be like tomahawks – while the legs are used at a slight distance like spears.

The Only Shop That Sells Stitched Products

Retail is the sale of goods and services from individuals or businesses to the customers. Retailers are part of an integrated system that is known as the supply chain. A retailer purchases goods or products in large quantities from manufacturers directly or through a wholesale, and then sells products to the consumer for a profit. Retailing can be done in either fixed locations like stores or markets, door-to-door or by delivery. In the 2000s, an increasing amount of retailing is done using online websites, electronic payment, and then delivered via a courier or via other services.

Retailing includes subordinated services, such as delivery. The term “retailer” is also applied where a service provider services the needs of a large number of individuals, such as for the public. Shops may be on residential streets, streets with few or no houses or in a shopping mall. Shopping streets may be for pedestrians only. Sometimes a shopping street has a partial or full roof to protect customers from precipitation. Online retailing, a type of electronic commerce used for business-to-consumer transactions and mail order, are forms of non-shop retailing.

Shopping in general refers to the act of buying products. Sometimes this is done to obtain necessities such as food and clothing; sometimes it is done as a recreational activity. Recreational shopping often involves window shopping (just looking, not buying) and browsing and does not always result in a purchase.

Bicycle With An Unique Security System

A bicycle, but most time it is just called a bike, is a human-powered, pedal-driven, single-track vehicle, having two wheels attached to a frame, one behind the other. A bicycle rider is called a cyclist, or bicyclist.

Bicycles were introduced in the 19th century in Europe and, as of 2003, number more than a billion worldwide, twice as many as automobiles. They are the principal means of transportation in many different regions.

They also provide a popular form of recreation, and have been adapted for use as children’s toys, general fitness, military and police applications, courier services, and bicycle racing.

The basic shape and configuration of a typical upright, or safety bicycle, has changed little since the first chain-driven model was developed around 1885.

But many details have been improved, especially since the advent of modern materials and computer-aided design. These have allowed for a proliferation of specialized designs for many types of cycling.

The bicycle’s invention has had an enormous effect on society, both in terms of culture and of advancing modern industrial methods. Several components that eventually played a key role in the development of the automobile were initially invented for use in the bicycle, including ball bearings, pneumatic tires, chain-driven sprockets, and tension-spoked wheels.

EPA Regulations Make It Tougher to Pay Electricity Bills

The NMA is here to save the day. The National Mining Association aids businesses and facilities such as metal coal producers so they can Americans Face Jump In Electricity Bills Due To Proposed EPA Regulations. “The impact of this regulation will be felt by families as they will spend more to heat and cool their homes. Those on fixed incomes and seniors will be forced to pay a disproportionately higher share of their monthly budget on utilities,” said Hal Quinn, CEO, National Mining Association.  Why should us as Americans feel perplexed by this?  Higher power costs additionally hit organizations in light of the fact that now producers need to reduction their intensity in terms of competition against other companies. This guideline is an overwhelming goal to reproduce the nation’s entire power network at high cost to houses and organizations everywhere on this extraordinary country.

 Presently, it is tricky to figure out what it will resemble quite a while from now on account of the shiny new regulations of the U.s. Ecological Protection Agency. Visit www.nma.org to take in more about what you can do about this. The people of the U.S. should not need to live in apprehension of whether they can bear the cost of power for their survival.

This post was sponsored, but opinions are my own

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